Article
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection.
The Journal of experimental medicine - 2 Nov 2020
Fournier Benjamin, Boutboul David, Bruneau Julie, Miot Charline, Boulanger Cécile, Malphettes Marion, Pellier Isabelle, Dunogué Bertrand, Terrier Benjamin, Suarez Felipe, Blanche Stéphane, Castelle Martin, Winter Sarah, Delecluse Henri-Jacques, Molina Thierry, Picard Capucine, Ehl Stephan, Moshous Despina, Galicier Lionel, Barlogis Vincent, Fischer Alain, Neven Bénédicte, Latour Sylvain
Abstract excerpt
Epstein-Barr virus (EBV) preferentially infects epithelial cells and B lymphocytes and sometimes T and NK lymphocytes. Persistence of EBV-infected cells results in severe lymphoproliferative disorders (LPDs). Diagnosis of EBV-driven T or NK cell LPD and chronic active EBV diseases (CAEBV) is difficult, often requiring biopsies. Herein, we report a flow-FISH cytometry assay that detects cells expressing...
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