Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2010

Herbert Bronwen, Patel Dilipkumar, Waddington Simon N, Eden Emily R, McAleenan Alexandra, Sun Xi-Ming, Soutar Anne K

Abstract excerpt

OBJECTIVE: To produce transgenic mice expressing the D374Y variant of the human proprotein convertase subtilisin/kexin type 9 (PCSK9) gene at physiological levels to investigate the mechanisms causing hypercholesterolemia and accelerated atherosclerosis. METHODS AND RESULTS: A bacterial artificial chromosome containing PCSK9 and its flanking regions was modified to introduce the D374Y mutation and a C-terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein B-100
Share to Apolipoproteins B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, Dietary

Share to Chromosomes, Artificial, Bacterial

Share to Hyperlipoproteinemia Type II

Share to Intestine, Small

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Source

Identifiers

PMID: 20448210
DOI: 10.1161/ATVBAHA.110.204040

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.PMID 20448210Read ↗

PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expressionSemantic proximity Read ↗

Induction of sustained hypercholesterolemia by single adeno-associated virus-mediated gene transfer of mutant hPCSK9.Semantic proximity Read ↗

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant.Semantic proximity Read ↗

New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol.Semantic proximity Read ↗

AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia.Semantic proximity Read ↗

Targeting PCSK9 for the treatment of hypercholesterolemia.Semantic proximity Read ↗

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.Semantic proximity Read ↗

Proprotein convertase subtilisin/kexin type 9: from genetics to clinical trials.Semantic proximity Read ↗

Engineered Red Blood Cells Carrying PCSK9 Inhibitors Persistently Lower LDL and Prevent ObesitySemantic proximity Read ↗

Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long-term inhibition.Semantic proximity Read ↗

The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation.Semantic proximity Read ↗

In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.