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Proteomic Analysis of Early HIV-1 Nucleoprotein Complexes

2 Jan 2013

Abstract excerpt

After entry into the cell, the early steps of the human immunodeficiency virus type 1 (HIV-1) replication cycle are mediated by two functionally distinct nucleoprotein complexes, the reverse transcription complex (RTC) and preintegration complex (PIC). These two unique viral complexes are responsible for the conversion of the single-stranded RNA genome into double-stranded DNA, transport of the DNA into the...

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PMID: 23282062
DOI: 10.1021/pr300869h

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