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Article

Examination of soluble integrin resistant mutants of foot-and-mouth disease virus.

Virology journal - 2 Jan 2013

Lawrence Paul, LaRocco Michael, Baxt Barry, Rieder Elizabeth

Abstract excerpt

BACKGROUND: Foot-and-mouth disease virus (FMDV) initiates infection via recognition of one of at least four cell-surface integrin molecules αvβ1, αvβ3, αvβ6, or αvβ8 by a highly conserved Arg-Gly-Asp (RGD) amino acid sequence motif located in the G-H loop of VP1. Within the animal host, the αvβ6 interaction is believed to be the most relevant. Sub-neutralizing levels of soluble secreted αvβ6 (ssαvβ6) was used as...

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Identifiers

PMID: 23282061
DOI: 10.1186/1743-422X-10-2
PMCID: PMC3547720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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