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Analysis of a Foot-and-Mouth Disease Virus Type A <sub>24</sub> Isolate Containing an SGD Receptor Recognition Site In Vitro and Its Pathogenesis in Cattle

27 Sept 2005

Abstract excerpt

Foot-and-mouth disease virus (FMDV) initiates infection by binding to integrin receptors via an Arg-Gly-Asp (RGD) sequence found in the G-H loop of the structural protein VP1. Following serial passages of a type A(24) Cruzeiro virus (A(24)Cru) in bovine, via tongue inoculation, a virus was generated which contained an SGD sequence in the cell receptor-binding site and expressed a turbid plaque phenotype in BHK-21...

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PMID: 16189001
DOI: 10.1128/jvi.79.20.12989-12998.2005

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