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Article

A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polμ and Polλ.

Nucleic acids research - 1 Oct 2013

Martin Maria Jose, Garcia-Ortiz Maria Victoria, Gomez-Bedoya Ana, Esteban Veronica, Guerra Susana, Blanco Luis

Abstract excerpt

Human DNA polymerases mu (Polµ) and lambda (Polλ) are X family members involved in the repair of double-strand breaks in DNA during non-homologous end joining. Crucial abilities of these enzymes include bridging of the two 3' single-stranded overhangs and trans-polymerization using one 3' end as primer and the other as template, to minimize sequence loss. In this context, we have studied the importance of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23935073
DOI: 10.1093/nar/gkt681
PMCID: PMC3799444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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