Article
Genomic variation by whole-genome SNP mapping arrays predicts time-to-event outcome in patients with chronic lymphocytic leukemia: a comparison of CLL and HapMap genotypes.
The Journal of molecular diagnostics : JMD - 1 Mar 2013
Schweighofer Carmen D, Coombes Kevin R, Majewski Tadeusz, Barron Lynn L, Lerner Susan, Sargent Rachel L, O'Brien Susan, Ferrajoli Alessandra, Wierda William G, Czerniak Bogdan A, Medeiros L Jeffrey, Keating Michael J, Abruzzo Lynne V
Abstract excerpt
Genomic abnormalities, such as deletions in 11q22 or 17p13, are associated with poorer prognosis in patients with chronic lymphocytic leukemia (CLL). We hypothesized that unknown regions of copy number variation (CNV) affect clinical outcome and can be detected by array-based single-nucleotide po...
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