Family history of lung cancer in never smokers with non-small-cell lung cancer and its association with tumors harboring EGFR mutations.

doi:10.1016/j.lungcan.2012.12.002

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Article

Family history of lung cancer in never smokers with non-small-cell lung cancer and its association with tumors harboring EGFR mutations.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2013

Gaughan Elizabeth M, Cryer Sarah K, Yeap Beow Y, Jackman David M, Costa Daniel B

Abstract excerpt

INTRODUCTION: Inherited susceptibility to lung cancer is understudied. Never smokers are an important subgroup of patients enriched for tumors harboring oncogene aberrations in the EGFR and ALK genes. We aimed to better characterize the incidence of family history of lung cancer among never smokers with NSCLC. METHODS: Clinicopathologic data, tumor genotype, family history of cancer, and specifically family...

Topics

Anaplastic Lymphoma Kinase
Carcinoma, Non-Small-Cell Lung
DNA Mutational Analysis
ErbB Receptors
Female
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Medical History Taking

Middle Aged

Mutation

Receptor Protein-Tyrosine Kinases

Retrospective Studies

Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 23273562
DOI: 10.1016/j.lungcan.2012.12.002
PMCID: PMC3566317

Genes

EGFR
ALK
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23273562-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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