Article
Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua.
BMC evolutionary biology - 29 Dec 2012
Sundaram Arvind Y M, Kiron Viswanath, Dopazo Joaquín, Fernandes Jorge M O
Abstract excerpt
BACKGROUND: Toll-like receptors (Tlrs) are major molecular pattern recognition receptors of the innate immune system. Atlantic cod (Gadus morhua) is the first vertebrate known to have lost most of the mammalian Tlr orthologues, particularly all bacterial recognising and other cell surface Tlrs. On the other hand, its genome encodes a unique repertoire of teleost-specific Tlrs. The aim of this study was to...
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