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Article

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

PloS one - 1 Jan 2012

Smith Stuart J, Wilson Martin, Ward Jennifer H, Rahman Cheryl V, Peet Andrew C, Macarthur Donald C, Rose Felicity R A J, Grundy Richard G, Rahman Ruman

Abstract excerpt

INTRODUCTION: Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture System (RCCS). METHODS: CNS cancer cell lines were grown in conventional 2D cultures and the RCCS and comparison with a cohort of 53...

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Source

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Identifiers

PMID: 23272238
DOI: 10.1371/journal.pone.0052335
PMCID: PMC3525561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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