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Article

Cardiac-specific overexpression of melanoma differentiation-associated gene-5 protects mice from lethal viral myocarditis.

Circulation. Heart failure - 1 Mar 2013

Philip Joseph, Xu Zhaohui, Bowles Neil E, Vallejo Jesus G

Abstract excerpt

BACKGROUND: Viral myocarditis is among the most common causes of heart failure in children and young adults. The RNA helicase melanoma differentiation-associated gene-5 (MDA5) is critical for host antiviral responses against members of the Picornaviridae family, such as encephalomyocarditis virus (EMCV). MDA5-knockout mice are highly susceptible to EMCV infection and develop significant myocardial injury and left...

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Identifiers

PMID: 23271791
DOI: 10.1161/CIRCHEARTFAILURE.112.969402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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