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Differential Replication of Pathogenic and Nonpathogenic Strains of West Nile Virus within Astrocytes

26 Dec 2012

Abstract excerpt

The severity of West Nile virus (WNV) infection in immunocompetent animals is highly strain dependent, ranging from avirulent to highly neuropathogenic. Here, we investigate the nature of this strain-specific restriction by analyzing the replication of avirulent (WNV-MAD78) and highly virulent (WNV-NY) strains in neurons, astrocytes, and microvascular endothelial cells, which comprise the neurovascular unit...

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PMID: 23269784
DOI: 10.1128/jvi.02577-12

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