Article
NONO couples the circadian clock to the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013
Kowalska Elzbieta, Ripperger Juergen A, Hoegger Dominik C, Bruegger Pascal, Buch Thorsten, Birchler Thomas, Mueller Anke, Albrecht Urs, Contaldo Claudio, Brown Steven A
Abstract excerpt
Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for wound healing in mice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.