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Article

Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer.

Scientific reports - 4 Nov 2015

Yu Yang, Dong Li, Li Dapeng, Chuai Shaokun, Wu Zhigang, Zheng Xiangqian, Cheng Yanan, Han Lei, Yu Jinpu, Gao Ming

Abstract excerpt

Some studies have demonstrated that familial non-medullary thyroid cancer (FNMTC) has a more aggressive clinical behavior compared to sporadic NMTC (SNMTC). However, FNMTC is difficult to differentiate from SNMTC by the morphology and immunohistochemistry. Although genes responsible for FNMTC were unclear, screening for rare germline mutations on known important tumor suppressor genes might offer more insights on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26530882
DOI: 10.1038/srep16129
PMCID: PMC4632085

Genes

APC
BRAF
BRCA1
BRCA2
GNAS
MEN1
MSH2
MSH6

Variants

Provenance

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