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Article

Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences.

Journal of the American Chemical Society - 9 Jan 2013

Leu Kevin, Kervio Eric, Obermayer Benedikt, Turk-MacLeod Rebecca M, Yuan Caterina, Luevano Jesus-Mario, Chen Eric, Gerland Ulrich, Richert Clemens, Chen Irene A

Abstract excerpt

Nonenzymatic, template-directed synthesis of nucleic acids is a paradigm for self-replicating systems. The evolutionary dynamics of such systems depend on several factors, including the mutation rates, relative replication rates, and sequence characteristics of mutant sequences. We measured the kinetics of correct and incorrect monomer insertion downstream of a primer-template mismatch (mutation), using a range...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23259600
DOI: 10.1021/ja3095558
PMCID: PMC3557965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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