Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.

doi:10.1172/JCI65833

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Article

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.

The Journal of clinical investigation - 1 Jan 2013

Verhaak Roel G W, Tamayo Pablo, Yang Ji-Yeon, Hubbard Diana, Zhang Hailei, Creighton Chad J, Fereday Sian, Lawrence Michael, Carter Scott L, Mermel Craig H, Kostic Aleksandar D, Etemadmoghadam Dariush, Saksena Gordon, Cibulskis Kristian, Duraisamy Sekhar, Levanon Keren, Sougnez Carrie, Tsherniak Aviad, Gomez Sebastian, Onofrio Robert, Gabriel Stacey, Chin Lynda, Zhang Nianxiang, Spellman Paul T, Zhang Yiqun, Akbani Rehan, Hoadley Katherine A, Kahn Ari, Köbel Martin, Huntsman David, Soslow Robert A, Defazio Anna, Birrer Michael J, Gray Joe W, Weinstein John N, Bowtell David D, Drapkin Ronny, Mesirov Jill P, Getz Gad, Levine Douglas A, Meyerson Matthew

Abstract excerpt

Because of the high risk of recurrence in high-grade serous ovarian carcinoma (HGS-OvCa), the development of outcome predictors could be valuable for patient stratification. Using the catalog of The Cancer Genome Atlas (TCGA), we developed subtype and survival gene expression signatures, which, when combined, provide a prognostic model of HGS-OvCa classification, named "Classification of Ovarian Cancer" (CLOVAR)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23257362
DOI: 10.1172/JCI65833
PMCID: PMC3533304

Genes

HGS
BRCA1
BRCA2

Provenance

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