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Article

Time to recurrence and survival in serous ovarian tumors predicted from integrated genomic profiles.

PloS one - 1 Jan 2011

Mankoo Parminder K, Shen Ronglai, Schultz Nikolaus, Levine Douglas A, Sander Chris

Abstract excerpt

BACKGROUND: Serous ovarian cancer (SeOvCa) is an aggressive disease with differential and often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas (TCGA) has provided rich molecular and genetic profiles from hundreds of primary surgical samples. These profiles confirm mutations of TP53 in ~100% of patients and an extraordinarily complex profile of DNA copy number changes with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22073136
DOI: 10.1371/journal.pone.0024709
PMCID: PMC3207809

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CPE

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