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miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

15 Aug 2010

Abstract excerpt

Hematopoietic stem cells (HSCs) are defined by their exclusive capacity to both self-renew and to give rise to multipotent progenitors (MPPs) that in turn differentiate into the mature blood cell lineages. The tumor suppressor p53, in addition to its role in the regulation of the cell cycle, plays an important role in HSC self-renewal, although it has not fully resolved. Here we report that in super-p53 mice...

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PMID: 20703086
DOI: 10.4161/cc.9.16.12598

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