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Article

Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment

19 Dec 2012

Abstract excerpt

Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has been shown to increase CSC proliferation and tumor growth. Here, we report that Lin28, a stem cell factor, binds to BMP4...

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PMID: 23255092
DOI: 10.4161/cc.23028

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