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Article

A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation.

Arthritis research & therapy - 1 Jan 2008

Beretta Lorenzo, Cossu Marta, Marchini Maurizio, Cappiello Francesca, Artoni Andrea, Motta Giovanna, Scorza Raffaella

Abstract excerpt

INTRODUCTION: Platelet aggregation may contribute to the pathogenesis of systemic sclerosis: following activation, platelets release significant amounts of serotonin - which promotes vasoconstriction and fibrosis, and further enhances aggregation. The C+1354T polymorphism in the exonic region of the serotonin 2A receptor gene determining the His452Tyr substitution was associated with blunted intracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Serotonin, 5-HT2A

Share to Scleroderma, Systemic

Source

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Identifiers

PMID: 18761744
DOI: 10.1186/ar2495
PMCID: PMC2592780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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