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Article

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.

European journal of human genetics : EJHG - 1 Jul 2010

Seddighzadeh Maria, Korotkova Marina, Källberg Henrik, Ding Bo, Daha Nina, Kurreeman Fina A S, Toes Rene E M, Huizinga Tom W, Catrina Anca I, Alfredsson Lars, Klareskog Lars, Padyukov Leonid

Abstract excerpt

It has repeatedly been suggested that the development of complex diseases can be elucidated by gene-gene interactions. Recently, we found that HTR2A, a member of the serotonin receptor family, is associated with rheumatoid arthritis (RA). This study was aimed to investigate the possibility of a gene-gene interaction between HTR2A and the major genetic risk factor for RA, HLA-DRB1 shared epitope (SE) alleles. We...

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Source

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Identifiers

PMID: 20179740
DOI: 10.1038/ejhg.2010.12
PMCID: PMC2987366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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