Association analysis between -308G/A and -238G/A TNF-alpha gene promoter polymorphisms and insulin resistance in Mexican women with gestational diabetes mellitus.

doi:10.2310/JIM.0b013e31827b98c9

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Article

Association analysis between -308G/A and -238G/A TNF-alpha gene promoter polymorphisms and insulin resistance in Mexican women with gestational diabetes mellitus.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Feb 2013

Guzmán-Flores Juan Manuel, Escalante Miguel, Sánchez-Corona José, García-Zapién Alejandra Guadalupe, Cruz-Quevedo Edhit Guadalupe, Muñoz-Valle José Francisco, Moran-Moguel María Cristina, Saldaña-Cruz Ana Miriam, Flores-Martínez Silvia Esperanza

Abstract excerpt

BACKGROUND: Gestational diabetes mellitus (GDM) is characterized by insulin resistance. It has been described that tumor necrosis factor α (TNF-α) plays a key role in the pathogenesis of insulin resistance; moreover, increased levels of this proinflammatory cytokine have been reported in women with GDM. Therefore, this study was aimed to assess the presence of associations between the -308G/A and -238G/A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23254337
DOI: 10.2310/JIM.0b013e31827b98c9

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