Article
Finding missing heritability in less significant Loci and allelic heterogeneity: genetic variation in human height.
PloS one - 1 Jan 2012
Zhang Ge, Karns Rebekah, Sun Guangyun, Indugula Subba Rao, Cheng Hong, Havas-Augustin Dubravka, Novokmet Natalija, Durakovic Zijad, Missoni Sasa, Chakraborty Ranajit, Rudan Pavao, Deka Ranjan
Abstract excerpt
Genome-wide association studies (GWAS) have identified many common variants associated with complex traits in human populations. Thus far, most reported variants have relatively small effects and explain only a small proportion of phenotypic variance, leading to the issues of 'missing' heritability and its explanation. Using height as an example, we examined two possible sources of missing heritability: first,...
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