Article
Extent of height variability explained by known height-associated genetic variants in an isolated population of the Adriatic coast of Croatia.
PloS one - 1 Jan 2011
Zhang Ge, Karns Rebekah, Sun Guangyun, Indugula Subba Rao, Cheng Hong, Havas-Augustin Dubravka, Novokmet Natalija, Rudan Dusko, Durakovic Zijad, Missoni Sasa, Chakraborty Ranajit, Rudan Pavao, Deka Ranjan
Abstract excerpt
BACKGROUND: Human height is a classical example of a polygenic quantitative trait. Recent large-scale genome-wide association studies (GWAS) have identified more than 200 height-associated loci, though these variants explain only 2∼10% of overall variability of normal height. The objective of this study was to investigate the variance explained by these loci in a relatively isolated population of European descent...
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