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Article

Dcas supports cell polarization and cell-cell adhesion complexes in development.

PloS one - 24 Aug 2010

Tikhmyanova Nadezhda, Tulin Alexei V, Roegiers Fabrice, Golemis Erica A

Abstract excerpt

Mammalian Cas proteins regulate cell migration, division and survival, and are often deregulated in cancer. However, the presence of four paralogous Cas family members in mammals (BCAR1/p130Cas, EFS/Sin1, NEDD9/HEF1/Cas-L, and CASS4/HEPL) has limited their analysis in development. We deleted the single Drosophila Cas gene, Dcas, to probe the developmental function of Dcas. Loss of Dcas had limited effect on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20808771
DOI: 10.1371/journal.pone.0012369
PMCID: PMC2927436

Genes

BCAR1
CASS4
EFS
NEDD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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