Article
FcγRIIa and FcγRIIIa polymorphisms in childhood primary immune thrombocytopenia: implications for disease pathogenesis and outcome.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 2013
Papagianni Andromachi, Economou Marina, Tragiannidis Athanasios, Karatza Eliza, Samarah Fekri, Gombakis Nikolaos, Athanassiadou-Piperopoulou Fani, Vavatsi-Christaki Norma, Athanassiou-Metaxa Miranda
Abstract excerpt
Primary immune thrombocytopenia (ITP) is the commonest acquired cause of bleeding in childhood. The aim of the present study was to evaluate the role of FcγRIIa and FcγRIIIa polymorphisms in the pathogenesis and therapeutic result of childhood ITP. The genotypic frequencies for two Fcγ receptor single-nucleotide polymorphisms, FcγRIIa-131 arginine (R) versus histidine (H) and FcγRIIIa-158 valine (V) versus...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.