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Article

Fcgamma receptor IIa and IIIa polymorphisms in childhood immune thrombocytopenic purpura.

British journal of haematology - 1 Jan 2003

Carcao Manuel D, Blanchette Victor S, Wakefield Cindy D, Stephens Derick, Ellis Janet, Matheson Kimberly, Denomme Gregory A

Abstract excerpt

Fcgamma receptor-mediated destruction of autoantibody-sensitized platelets is central to the immune pathophysiology of childhood immune thrombocytopenic purpura (ITP). Allelic variants exist among the random population for some Fcgamma receptors. The variants represent single nucleotide polymorphisms, leading to functional differences in the ability to bind immunoglobulin (Ig)G or IgG subclasses. The genotypic...

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Source

Identifiers

PMID: 12492589
DOI: 10.1046/j.1365-2141.2003.04033.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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