Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status

18 Dec 2012

Abstract excerpt

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and current therapeutic strategies aim to target the hypoxic response. One way in which this is done is by blocking hypoxia-induced angiogenesis. Antiangiogenic therapies show some therapeutic potential with increased disease-free survival, but these initial promising results are short lived and followed by tumor progression. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Stress, Anesthesia, and Immune Response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23248117
DOI: 10.1158/0008-5472.can-12-2505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α StatusPMID 23248117Read ↗

Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools.Semantic proximity Read ↗

Enrichment of breast cancer stem cells following cytotoxic chemotherapy is mediated by hypoxia-inducible factorsSemantic proximity Read ↗

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells.Semantic proximity Read ↗

Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines.Semantic proximity Read ↗

Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors.Semantic proximity Read ↗

Estrogen Receptor β4 Regulates Chemotherapy Resistance and Induces Cancer Stem Cells in Triple Negative Breast CancerSemantic proximity Read ↗

Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cellsSemantic proximity Read ↗

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cellsSemantic proximity Read ↗

FOXA1 expression affects the proliferation activity of luminal breast cancer stem cell populationsSemantic proximity Read ↗

Breast cancer stem cell-like cells generated during TGFβ-induced EMT are radioresistantSemantic proximity Read ↗

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem CellsSemantic proximity Read ↗

Roles of hypoxia, stem cells and epithelial–mesenchymal transition in the spread and treatment resistance of head and neck cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.