Article
Genetic variants in genes related to lipid metabolism and atherosclerosis, dyslipidemia and atorvastatin response.
Clinica chimica acta; international journal of clinical chemistry - 18 Feb 2013
Rodrigues A C, Sobrino B, Genvigir F D V, Willrich M A V, Arazi S S, Dorea E L, Bernik M M S, Bertolami M, Faludi A A, Brion M J, Carracedo A, Hirata M H, Hirata R D C
Abstract excerpt
OBJECTIVE: Using candidate gene approach, we have investigated the effect of single nucleotide polymorphism (SNP) in genes related to lipid metabolism and atherosclerosis on dyslipidemia and atorvastatin response. METHODS: The study included 157 patients treated with atorvastatin and 145 controls. Genomic DNA was isolated and genotyped using SNPlex technology. RESULTS: Allele and genotype disease association test...
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