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Article

Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene.

FEBS letters - 31 Jan 2013

Komori Aya, Suzuki Munenori, Seki Hikaru, Nishizawa Tomoko, Meyer Jacobus Johannes Marion, Shimizu Hideaki, Yokoyama Shigeyuki, Muranaka Toshiya

Abstract excerpt

Artemisinin is an antimalarial sesquiterpenoid isolated from the aerial parts of the plant Artemisia annua. CYP71AV1, a cytochrome P450 monooxygenase was identified in the artemisinin biosynthetic pathway. CYP71AV1 catalyzes three successive oxidation steps at the C12 position of amorpha-4,11-diene to produce artemisinic acid. In this study, we isolated putative CYP71AV1 orthologs in different species of...

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PMID: 23246612
DOI: 10.1016/j.febslet.2012.11.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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