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Article

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

Immunity - 24 Jan 2013

Koblansky A Alicia, Jankovic Dragana, Oh Hyunju, Hieny Sara, Sungnak Waradon, Mathur Ramkumar, Hayden Matthew S, Akira Shizuo, Sher Alan, Ghosh Sankar

Abstract excerpt

Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii-infected mice. However, TLR11 only modestly affects survival of T. gondii-challenged mice. We report that TLR12, a previously uncharacterized TLR, also recognized TgPRF. TLR12 was sufficient for recognition of TgPRF by...

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Identifiers

PMID: 23246311
DOI: 10.1016/j.immuni.2012.09.016
PMCID: PMC3601573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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