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Article

Toxoplasma gondii- derived profilin triggers human toll-like receptor 5-dependent cytokine production.

Journal of innate immunity - 1 Jan 2014

Salazar Gonzalez Rosa Maria, Shehata Hesham, O'Connell Michael J, Yang Yanfen, Moreno-Fernandez Maria E, Chougnet Claire A, Aliberti Julio

Abstract excerpt

Up to a third of the world's population is infected with Toxoplasma gondii. Natural infection in humans can be life threatening during pregnancy and in immunocompromised individuals. Toll-like receptor (TLR) 11 is the mouse innate sensor that recognizes T. gondii profilin; however, in humans the TLR11 gene leads to transcription of no functional protein. Herein, by using a multiple sequence alignment phylogenetic...

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Identifiers

PMID: 24861338
DOI: 10.1159/000362367
PMCID: PMC4141014

Genes

TLR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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