Article
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Science translational medicine - 12 Dec 2012
Sheng Zejuan, Zhang Shuo, Bustos Daisy, Kleinheinz Tracy, Le Pichon Claire E, Dominguez Sara L, Solanoy Hilda O, Drummond Jason, Zhang Xiaolin, Ding Xiao, Cai Fang, Song Qinghua, Li Xianting, Yue Zhenyu, van der Brug Marcel P, Burdick Daniel J, Gunzner-Toste Janet, Chen Huifen, Liu Xingrong, Estrada Anthony A, Sweeney Zachary K, Scearce-Levie Kimberly, Moffat John G, Kirkpatrick Donald S, Zhu Haitao
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD). Although biochemical studies have shown that certain PD mutations confer elevated kinase activity in vitro on LRRK2, there are no methods available to directly monitor LRRK2 kinase activity in vivo. We demonstrate that LRRK2 autophosphorylation on Ser(1292) occurs in vivo and is enhanced by...
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