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Article

Cell fusion in tumor development: accelerated genetic evolution.

Critical reviews in oncogenesis - 1 Jan 2013

Harkness Ty, Weaver Beth A, Alexander Caroline M, Ogle Brenda M

Abstract excerpt

The majority of human tumor cells have highly aberrant karyotypes, typically ascribed to errors during tumor cell division, potentially linked to a failure of DNA repair, or telomeric insufficiency. Here we discuss another option, that of cell fusion which can lead to the re-assortment of chromosomes during post-fusion mitosis. The observation of hyperdiploid cells has a long history in cancer genetics, but the...

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Identifiers

PMID: 23237551
DOI: 10.1615/critrevoncog.v18.i1-2.30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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