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Article

An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations.

Stem cell reports - 14 Apr 2015

Burrows Jeffrey T A, Pearson Bret J, Scott Ian C

Abstract excerpt

The Mediator complex has recently been shown to be a key player in the maintenance of embryonic and induced pluripotent stem cells. However, the in vivo consequences of loss of many Mediator subunits are unknown. We identified med14 as the gene affected in the zebrafish logelei (log) mutant, which displayed a morphological arrest by 2 days of development. Surprisingly, microarray analysis showed that...

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Identifiers

PMID: 25772472
DOI: 10.1016/j.stemcr.2015.02.006
PMCID: PMC4400641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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