Article
Genotype imputation via matrix completion.
Genome research - 1 Mar 2013
Chi Eric C, Zhou Hua, Chen Gary K, Del Vecchyo Diego Ortega, Lange Kenneth
Abstract excerpt
Most current genotype imputation methods are model-based and computationally intensive, taking days to impute one chromosome pair on 1000 people. We describe an efficient genotype imputation method based on matrix completion. Our matrix completion method is implemented in MATLAB and tested on real data from HapMap 3, simulated pedigree data, and simulated low-coverage sequencing data derived from the 1000 Genomes...
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