Article
Intracellularly induced cyclophilins play an important role in stress adaptation and virulence of Brucella abortus.
Infection and immunity - 1 Feb 2013
Roset Mara S, García Fernández Lucía, DelVecchio Vito G, Briones Gabriel
Abstract excerpt
Brucella is an intracellular bacterial pathogen that causes the worldwide zoonotic disease brucellosis. Brucella virulence relies on its ability to transition to an intracellular lifestyle within host cells. Thus, this pathogen must sense its intracellular localization and then reprogram gene expression for survival within the host cell. A comparative proteomic investigation was performed to identify...
Topics
- Adaptation, Physiological
- Animals
- Bacterial Proteins
- Brucella abortus
- Brucellosis
- Cell Line, Tumor
- Cyclophilins
- Female
- Gene Expression
- Gene Expression Regulation, Bacterial
- HeLa Cells
- Humans
- Mice
- Mice, Inbred BALB C
- Mutation
- Proteomics
- Stress, Physiological
- Virulence