Article
Effects of natural mutations in the ramRA locus on invasiveness of epidemic fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates.
The Journal of infectious diseases - 1 Mar 2013
Giraud Etienne, Baucheron Sylvie, Virlogeux-Payant Isabelle, Nishino Kunihiko, Cloeckaert Axel
Abstract excerpt
BACKGROUND: Fluoroquinolone (FQ) resistance is increasing worldwide among Salmonella species. Among the mechanisms involved, increased efflux via the tripartite AcrAB-TolC efflux system is mainly modulated through control of expression via the ramRA regulatory locus gene products. Interestingly, in some reference strains these have also been experimentally shown to regulate cell invasion-related genes of the type...
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