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Function of Candida glabrata ABC transporter gene, PDH1

7 Jan 2003

Abstract excerpt

The rapid increase in azole resistance during treatment of patients infected with Candida glabrata may be due to increased azole efflux mediated by ABC transporters, as occurs with increased expression of PDR5 in Saccharomyces cerevisiae. Two known C. glabrata homologues of PDR5 influencing azole susceptibility are PDH1 (CgCDR2) and CgCDR1. Disruption of PDH1 in a cgcdr1::ura3 strain increased susceptibility to...

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PMID: 12557277
DOI: 10.1002/yea.962

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