Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.

PloS one - 1 Jan 2012

Spellicy Catherine J, Northrup Hope, Fletcher Jack M, Cirino Paul T, Dennis Maureen, Morrison Alanna C, Martinez Carla A, Au Kit Sing

Abstract excerpt

The objective of this study was to examine the relation between the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and behaviors related to attention- deficit/hyperactivity disorder (ADHD) in individuals with myelomeningocele. The rationale for the study was twofold: folate metabolizing g...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Attention Deficit Disorder with Hyperactivity
Share to Behavior
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Hispanic or Latino

Share to Metabolic Networks and Pathways

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 23227261
DOI: 10.1371/journal.pone.0051330
PMCID: PMC3515551

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23227261-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.PMID 23227261Read ↗

Deep sequencing study of the MTHFR gene to identify variants associated with myelomeningocele.Semantic proximity Read ↗

Mutations in folate transporter genes and risk for human myelomeningocele.Semantic proximity Read ↗

Maternal gene-micronutrient interactions related to one-carbon metabolism and the risk of myelomeningocele among offspring.Semantic proximity Read ↗

Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder.Semantic proximity Read ↗

Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele.Semantic proximity Read ↗

Evaluation of C677T Polymorphism of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in various Neurological DisordersSemantic proximity Read ↗

[Methylenetetrahydrofolate reductase polymorphisms as risk factors for myelomeningocele].Semantic proximity Read ↗

Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems.Semantic proximity Read ↗

Evidence of gene-gene interactions between MTHFD1 and MTHFR in relation to anterior encephalocele susceptibility in Northeast India.Semantic proximity Read ↗

Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.Semantic proximity Read ↗

Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.Semantic proximity Read ↗

Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.