Article
Asthma discordance in twins is linked to epigenetic modifications of T cells.
PloS one - 1 Jan 2012
Runyon R Scott, Cachola Leslie M, Rajeshuni Nitya, Hunter Tessa, Garcia Marco, Ahn Regina, Lurmann Fred, Krasnow Ruth, Jack Lisa M, Miller Rachel L, Swan Gary E, Kohli Arunima, Jacobson Amanda C, Nadeau Kari C
Abstract excerpt
T cells mediate the inflammatory responses observed in asthma among genetically susceptible individuals and have been suspected to be prone to epigenetic regulation. However, these relationships are not well established from past clinical studies that have had limited capacity to control for the effects of variable genetic predisposition and early environmental exposures. Relying on a cohort of monozygotic twins...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.