Article
Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.
PLoS biology - 1 Jan 2012
Xiong Bo, Bayat Vafa, Jaiswal Manish, Zhang Ke, Sandoval Hector, Charng Wu-Lin, Li Tongchao, David Gabriela, Duraine Lita, Lin Yong-Qi, Neely G Gregory, Yamamoto Shinya, Bellen Hugo J
Abstract excerpt
Rhodopsins (Rhs) are light sensors, and Rh1 is the major Rh in the Drosophila photoreceptor rhabdomere membrane. Upon photoactivation, a fraction of Rh1 is internalized and degraded, but it remains unclear how the rhabdomeric Rh1 pool is replenished and what molecular players are involved. Here, we show that Crag, a DENN protein, is a guanine nucleotide exchange factor for Rab11 that is required for the...
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