Article
Loci associated with skin pigmentation identified in African populations.
Science (New York, N.Y.) - 17 Nov 2017
Crawford Nicholas G, Kelly Derek E, Hansen Matthew E B, Beltrame Marcia H, Fan Shaohua, Bowman Shanna L, Jewett Ethan, Ranciaro Alessia, Thompson Simon, Lo Yancy, Pfeifer Susanne P, Jensen Jeffrey D, Campbell Michael C, Beggs William, Hormozdiari Farhad, Mpoloka Sununguko Wata, Mokone Gaonyadiwe George, Nyambo Thomas, Meskel Dawit Wolde, Belay Gurja, Haut Jake, Rothschild Harriet, Zon Leonard, Zhou Yi, Kovacs Michael A, Xu Mai, Zhang Tongwu, Bishop Kevin, Sinclair Jason, Rivas Cecilia, Elliot Eugene, Choi Jiyeon, Li Shengchao A, Hicks Belynda, Burgess Shawn, Abnet Christian, Watkins-Chow Dawn E, Oceana Elena, Song Yun S, Eskin Eleazar, Brown Kevin M, Marks Michael S, Loftus Stacie K, Pavan William J, Yeager Meredith, Chanock Stephen, Tishkoff Sarah A
Abstract excerpt
Despite the wide range of skin pigmentation in humans, little is known about its genetic basis in global populations. Examining ethnically diverse African genomes, we identify variants in or near SLC24A5, MFSD12, DDB1, TMEM138, OCA2, and HERC2 that are significantly associated with skin pigmentation. Genetic evidence indicates that the light pigmentation variant at SLC24A5 was introduced into East Africa by gene...
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