Article
Genetic association of IFN-γ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
Archives of dermatological research - 1 May 2013
Charli-Joseph Yann, Lima Guadalupe, Ramos-Bello Dolores, Aguilar Diana, Orozco-Topete Rocío, Llorente Luis
Abstract excerpt
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, but potentially life-threatening diseases, characterized by widespread epidermal necrosis and are predominantly drug induced. There is a paucity of data regarding the role of cytokine and cytokine receptors polymorphisms in the pathoimmunology of SJS/TEN. The aim of this study was to investigate the role of TNF-α-308, IFN-γ +874, IL-10-1082,...
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