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Article

Affinofile profiling: how efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV.

Virology - 5 Jan 2013

Chikere Kelechi, Chou Tom, Gorry Paul R, Lee Benhur

Abstract excerpt

HIV-1 envelope (Env) uses CD4 and a coreceptor (CCR5 and/or CXCR4) for viral entry. The efficiency of receptor/coreceptor mediated entry has important implications for HIV pathogenesis and transmission. The advent of CCR5 inhibitors in clinical use also underscores the need for quantitative and p...

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Share to CD4 Antigens
Share to High-Throughput Screening Assays
Share to HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Receptors, CCR5

Share to Receptors, CXCR4

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Source

Open in PubMed Open full text

Identifiers

PMID: 23217618
DOI: 10.1016/j.virol.2012.09.043
PMCID: PMC3522187

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23217618-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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