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Article

Nonallelic homologous recombination between retrotransposable elements is a driver of de novo unbalanced translocations.

Genome research - 1 Mar 2013

Robberecht Caroline, Voet Thierry, Zamani Esteki Masoud, Nowakowska Beata A, Vermeesch Joris R

Abstract excerpt

Large-scale analysis of balanced chromosomal translocation breakpoints has shown nonhomologous end joining and microhomology-mediated repair to be the main drivers of interchromosomal structural aberrations. Breakpoint sequences of de novo unbalanced translocations have not yet been investigated systematically. We analyzed 12 de novo unbalanced translocations and mapped the breakpoints in nine. Surprisingly, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Source

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Identifiers

PMID: 23212949
DOI: 10.1101/gr.145631.112
PMCID: PMC3589530

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