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Recurrent DNA inversion rearrangements in the human genome

27 Mar 2007

Abstract excerpt

Several lines of evidence suggest that reiterated sequences in the human genome are targets for nonallelic homologous recombination (NAHR), which facilitates genomic rearrangements. We have used a PCR-based approach to identify breakpoint regions of rearranged structures in the human genome. In particular, we have identified intrachromosomal identical repeats that are located in reverse orientation, which may...

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PMID: 17389356
DOI: 10.1073/pnas.0701631104

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