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Article

Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes.

The Journal of investigative dermatology - 1 Jul 2017

Hobbs Ryan P, Smith Susan H, Getsios Spiro

Abstract excerpt

Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

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Share to Cell Differentiation
Share to Connexin 43
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Peptide Fragments

Share to Polymorphism, Genetic

Share to Psoriasis

Share to Signal Transduction

Source

Identifiers

PMID: 28390815
DOI: 10.1016/j.jid.2017.01.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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