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Article

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

Science signaling - 13 Oct 2009

Liu Caini, Qian Wen, Qian Youcun, Giltiay Natalia V, Lu Yi, Swaidani Shadi, Misra Saurav, Deng Li, Chen Zhijian J, Li Xiaoxia

Abstract excerpt

Interleukin-17 (IL-17), a proinflammatory cytokine mainly produced by cells of the T helper 17 (T(H)17) lineage, is required for host defense against bacterial and fungal infections and plays a critical role in the pathogenesis of inflammatory and autoimmune diseases. Act1 is an essential adaptor...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

Share to TNF Receptor-Associated Factor 6

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Source

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Identifiers

PMID: 19825828
DOI: 10.1126/scisignal.2000382
PMCID: PMC3182834

Genes

TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19825828-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.PMID 19825828Read ↗

SCF <sup>FBXW11</sup> complex targets interleukin-17 receptor A for ubiquitin-proteasome-mediated degradationSemantic proximity Read ↗

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3Semantic proximity Read ↗

Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling.Semantic proximity Read ↗

TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A ExpressionSemantic proximity Read ↗

NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6.Semantic proximity Read ↗

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.Semantic proximity Read ↗

Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10–IRF1–Act1 Axis in Autoimmune DiseasesSemantic proximity Read ↗

IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling.Semantic proximity Read ↗

Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17–Mediated Pathology and Signaling ProcessesSemantic proximity Read ↗

Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndromeSemantic proximity Read ↗

TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.Semantic proximity Read ↗

Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramerSemantic proximity Read ↗

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