Article
An examination of respiratory distress and chromosomal abnormalities in the offspring of male mice treated with ethylnitrosourea.
Mutation research - 1 Apr 1990
Nomura T, Gotoh H, Namba T
Abstract excerpt
A functional defect (respiratory distress), in addition to morphological defects, was induced in the offspring of male ICR mice treated with ethylnitrosourea (ENU) before mating. ENU (100 and 50 micrograms/g) was injected intraperitoneally into adult male ICR mice that were then mated with untreated females. After the cesarian operation on the 18th day of gestation, fetuses were resuscitated. In the apneic...
Topics
- Abnormalities, Drug-Induced
- Animals
- Chromosome Aberrations
- Ethylnitrosourea
- Karyotyping
- Male
- Mice
- Mice, Inbred ICR
- Mutation
- Respiratory Insufficiency
- Spermatogonia